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CIBCB
2005
IEEE
13 years 10 months ago
Intrinsic Disorder and Protein modifications: Building an SVM Predictor for Methylation
Abstract-Post-translational protein modifications play an important role in many protein pathways and interactions. It has been hypothesized that modifications to proteins occur in...
Kenneth Daily, Predrag Radivojac, A. Keith Dunker
CIBCB
2005
IEEE
13 years 10 months ago
A Neural Network for Predicting Protein Disorder using Amino Acid Hydropathy Values
— Proteins have been discovered to contain ordered regions and disordered regions, where ordered regions have a defined three-dimensional (3D) structure and disordered regions d...
Deborah Stoffer, L. Gwenn Volkert
ADC
2006
Springer
158views Database» more  ADC 2006»
13 years 10 months ago
Dimensionality reduction in patch-signature based protein structure matching
Searching bio-chemical structures is becoming an important application domain of information retrieval. This paper introduces a protein structure matching problem and formulates i...
Zi Huang, Xiaofang Zhou, Dawei Song, Peter Bruza
IPPS
2006
IEEE
13 years 10 months ago
A method to improve structural modeling based on conserved domain clusters
—Homology modeling requires an accurate alignment between a query sequence and its homologs with known three-dimensional (3D) information. Current structural modeling techniques ...
Fa Zhang, Lin Xu, Bo Yuan
CIBCB
2006
IEEE
13 years 10 months ago
Aggregating Homologous Protein Families in Evolutionary Reconstructions of Herpesviruses
Abstract–Protein families can be used to reconstruct evolutionary histories of organisms. The accuracy of protein assignment to such families is critical for the success of such ...
Boris Mirkin, Renata da Silva Camargo, Trevor I. F...
WABI
2007
Springer
13 years 10 months ago
Shotgun Protein Sequencing
Although snake venom proteins have been proven instrumental in the design of blood clotting and cytostatic breast cancer drugs, the main method in use to sequence these unknown pr...
Pavel A. Pevzner
BIRD
2007
Springer
150views Bioinformatics» more  BIRD 2007»
13 years 10 months ago
Bayesian Inference for 2D Gel Electrophoresis Image Analysis
Two-dimensional gel electrophoresis (2DGE) is a technique to separate individual proteins in biological samples. The 2DGE technique results in gel images where proteins appear as d...
Ji Won Yoon, Simon J. Godsill, ChulHun Kang, Tae-S...
BIRD
2007
Springer
107views Bioinformatics» more  BIRD 2007»
13 years 10 months ago
Prediction of Structurally-Determined Coiled-Coil Domains with Hidden Markov Models
The coiled-coil protein domain is a widespread structural motif known to be involved in a wealth of key interactions in cells and organisms. Coiled-coil recognition and prediction ...
Piero Fariselli, Daniele Molinini, Rita Casadio, A...
ISVD
2007
IEEE
13 years 10 months ago
Decoy Discrimination Using Contact Potentials Based on Delaunay Tessellation of Hydrated Proteins
Three strategies are presented for developing a knowledge-based statistical contact potential from computationally hydrated proteins that may be useful in studies of protein foldi...
Gregory M. Reck, Iosif I. Vaisman
ESCIENCE
2007
IEEE
13 years 10 months ago
eResearch Solutions for High Throughput Structural Biology
Structural biology research places significant demands upon computing and informatics infrastructure. Protein production, crystallization and X-ray data collection require solutio...
Noel G. Faux, Anthony Beitz, Mark A. Bate, Abdulla...