NAR
2011
12 years 11 months ago
2011
The polyglutamine diseases are caused in part by a gain-of-function mechanism of neuronal toxicity involving protein conformational changes that result in the formation and deposi...
NAR
2010
12 years 11 months ago
2010
Nucleic acid-binding proteins are involved in a great number of cellular processes. Understanding the mechanisms underlying these proteins first requires the identification of spe...
NAR
2010
12 years 11 months ago
2010
During cell division/mitosis, a specific subset of proteins is spatially and temporally assembled into protein super complexes in three distinct regions, i.e. centrosome/spindle p...
NAR
2010
12 years 11 months ago
2010
: Growth and development of plants depends on uptake and assimilation of nutrients. Many assimilation products of macronutrients are not only essential for plant growth but also ha...
NAR
2010
12 years 11 months ago
2010
Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes thr...
JMLR
2010
2010
Predicting the functions of proteins in Protein-Protein Interaction networks from global information
12 years 11 months ago
In this work we present a novel approach to predict the function of proteins in protein-protein interaction (PPI) networks. We classify existing approaches into inductive and tran...
BMCBI
2011
12 years 11 months ago
2011
Background: The way mechanical stress is distributed inside and propagated by proteins and other biopolymers largely defines their function. Yet, determining the network of intera...
BMCBI
2011
12 years 11 months ago
2011
Background: Viral zoonosis, the transmission of a virus from its primary vertebrate reservoir species to humans, requires ubiquitous cellular proteins known as receptor proteins. ...
BMCBI
2011
12 years 11 months ago
2011
Background: Outer membrane proteins (OMPs) are frequently found in the outer membranes of gram-negative bacteria, mitochondria and chloroplasts and have been found to play diverse...
BMCBI
2011
12 years 11 months ago
2011
Background: Remote homology detection is a hard computational problem. Most approaches have trained computational models by using either full protein sequences or multiple sequenc...