BMCBI
2008
13 years 4 months ago
2008
Background: Similarity inference, one of the main bioinformatics tasks, has to face an exponential growth of the biological data. A classical approach used to cope with this data ...
BMCBI
2008
13 years 4 months ago
2008
Background: The structure of many eukaryotic cell regulatory proteins is highly modular. They are assembled from globular domains, segments of natively disordered polypeptides and...
BMCBI
2008
13 years 4 months ago
2008
Background: Several eukaryotic proteins associated to the extracellular leaflet of the plasma membrane carry a Glycosylphosphatidylinositol (GPI) anchor, which is linked to the C-...
BMCBI
2008
13 years 4 months ago
2008
Background: As one of the most common protein post-translational modifications, glycosylation is involved in a variety of important biological processes. Computational identificat...
BMCBI
2008
13 years 4 months ago
2008
Background: Protein structural alignment provides a fundamental basis for deriving principles of functional and evolutionary relationships. It is routinely used for structural cla...
BMCBI
2008
13 years 4 months ago
2008
Background: Determining the function of uncharacterized proteins is a major challenge in the post-genomic era due to the problem's complexity and scale. Identifying a protein...
BMCBI
2008
13 years 4 months ago
2008
Background: The development and improvement of reliable computational methods designed to evaluate the quality of protein models is relevant in the context of protein structure re...
BMCBI
2008
13 years 4 months ago
2008
Background: The principles of protein folding and evolution pose problems of very high inherent complexity. Often these problems are tackled using simplified protein models, e.g. ...
BMCBI
2008
13 years 4 months ago
2008
Background: Target identification is important for modern drug discovery. With the advances in the development of molecular docking, potential binding proteins may be discovered b...
BMCBI
2008
13 years 4 months ago
2008
Background: Structural alignment is an important step in protein comparison. Well-established methods exist for solving this problem under the assumption that the structures under...