JCB
2006
13 years 4 months ago
2006
Abstract We present a new approach for aligning families of 2D gels. Instead of choosing one of the gels as reference and performing pairwise alignment, we construct an ideal gel t...
BMCBI
2007
13 years 4 months ago
2007
Background: Thermophilic organisms are able to live at high temperatures ranging from 50 to > 100°C. Their proteins must be sufficiently stable to function under these extreme...
ESWA
2006
13 years 4 months ago
2006
Proteomics is a field dedicated to the analysis and identification of proteins within an organism. Within proteomics, two-dimensional electrophoresis (2-DE) is currently unrivalle...
BMCBI
2007
13 years 4 months ago
2007
Background: Phylogenetic profiles record the occurrence of homologs of genes across fully sequenced organisms. Proteins with similar profiles are typically components of protein c...
BMCBI
2007
13 years 4 months ago
2007
Background: Identification of protein interacting sites is an important task in computational molecular biology. As more and more protein sequences are deposited without available...
BMCBI
2007
13 years 4 months ago
2007
Background: When proteins are subjected to proteolytic digestion and analyzed by mass spectrometry using a method such as 2D LC MS/MS, only a portion of the proteotypic peptides a...
BMCBI
2007
13 years 4 months ago
2007
Background: Protein interactions support cell organization and mediate its response to any specific stimulus. Recent technological advances have produced large data-sets that aim ...
BMCBI
2007
13 years 4 months ago
2007
Background: Protein structural data has increased exponentially, such that fast and accurate tools are necessary to access structure similarity search. To improve the search speed...
BMCBI
2007
13 years 4 months ago
2007
Background: A widely-used approach for discovering functional and physical interactions among proteins involves phylogenetic profile comparisons (PPCs). Here, proteins with simila...
IJBRA
2008
13 years 4 months ago
2008
: Functions of a protein are mainly determined by its structure. Surface cavities, also called pockets or clefts, are ordinarily regarded as potentially active sites where the prot...