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RECOMB
2012
Springer
7 years 21 days ago
A Model for Biased Fractionation after Whole Genome Duplication
Background: Paralog reduction, the loss of duplicate genes after whole genome duplication (WGD) is a pervasive process. Whether this loss proceeds gene by gene or through deletion...
David Sankoff, Chunfang Zheng, Baoyong Wang
RECOMB
2012
Springer
7 years 21 days ago
Reconstructing Boolean Models of Signaling
Abstract. Since the first emergence of protein-protein interaction networks, more than a decade ago, they have been viewed as static scaffolds of the signaling-regulatory events ...
Roded Sharan, Richard M. Karp
RECOMB
2012
Springer
7 years 21 days ago
Estimating the Accuracy of Multiple Alignments and its Use in Parameter Advising
We develop a novel and general approach to estimating the accuracy of protein multiple sequence alignments without knowledge of a reference alignment, and use our approach to addre...
Dan F. DeBlasio, Travis J. Wheeler, John D. Kececi...
RECOMB
2012
Springer
7 years 21 days ago
Recovering the Tree-Like Trend of Evolution Despite Extensive Lateral Genetic Transfer: A Probabilistic Analysis
Abstract. Lateral gene transfer (LGT) is a common mechanism of nonvertical evolution where genetic material is transferred between two more or less distantly related organisms. It ...
Sebastien Roch, Sagi Snir
RECOMB
2012
Springer
7 years 21 days ago
Simultaneous Reconstruction of Multiple Signaling Pathways via the Prize-Collecting Steiner Forest Problem
Signaling networks are essential for cells to control processes such as growth and response to stimuli. Although many “omic” data sources are available to probe signaling pathw...
Nurcan Tuncbag, Alfredo Braunstein, Andrea Pagnani...
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