CANDC
2005
ACM
13 years 4 months ago
2005
ACM
High throughput virtual screening is acknowledged as the initial means for identifying hit compounds that will be eventually transformed to leads or drug candidates. To improve qu...
BMCBI
2005
13 years 4 months ago
2005
Background: Profile-profile methods have been used for some years now to detect and align homologous proteins. The best such methods use information from the background distributi...
BMCBI
2006
13 years 4 months ago
2006
Background: Many biological processes involve the physical interaction between protein domains. Understanding these functional associations requires knowledge of the molecular str...
BMCBI
2008
13 years 4 months ago
2008
Background: Identifying the active site of an enzyme is a crucial step in functional studies. While protein sequences and structures can be experimentally characterized, determini...
BMCBI
2007
13 years 4 months ago
2007
Background: Many algorithms exist for protein structural alignment, based on internal protein coordinates or on explicit superposition of the structures. These methods are usually...
BMCBI
2010
13 years 4 months ago
2010
Background: The ability to design thermostable proteins is theoretically important and practically useful. Robust and accurate algorithms, however, remain elusive. One critical pr...
BIOINFORMATICS
2007
13 years 4 months ago
2007
Motivation: Protein–protein complexes are known to play key roles in many cellular processes. However, they are often not accessible to experimental study because of their low s...
UAI
1997
13 years 5 months ago
1997
Recently several researchers have investigated techniques for using data to learn Bayesian networks containing compact representations for the conditional probability distribution...
SODA
1997
ACM
13 years 5 months ago
1997
ACM
Given two planar polylines T and P with n and m edges, respectively, we present an O m2 n2 time, O mn space algorithm to nd portions of the text" T which are similar in sh...
GECCO
2003
Springer
13 years 9 months ago
2003
Springer
We have developed an evolutionary approach for the flexible docking that is now an important component of a rational drug design. This automatic docking tool, referred to as the G...