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PLOSCB
2016
66views more  PLOSCB 2016»
3 years 15 days ago
Faster Adaptation in Smaller Populations: Counterintuitive Evolution of HIV during Childhood Infection
Analysis of HIV-1 gene sequences sampled longitudinally from infected individuals can reveal the evolutionary dynamics that underlie associations between disease outcome and viral...
Jayna Raghwani, Samir Bhatt, Oliver G. Pybus
PLOSCB
2016
56views more  PLOSCB 2016»
3 years 15 days ago
Josephin Domain Structural Conformations Explored by Metadynamics in Essential Coordinates
The Josephin Domain (JD), i.e. the N-terminal domain of Ataxin 3 (At3) protein, is an interesting example of competition between physiological function and aggregation risk. In fa...
Marco A. Deriu, Gianvito Grasso, Jack A. Tuszynski...
PLOSCB
2016
65views more  PLOSCB 2016»
3 years 15 days ago
Enhanced Sensitivity to Rapid Input Fluctuations by Nonlinear Threshold Dynamics in Neocortical Pyramidal Neurons
The way in which single neurons transform input into output spike trains has fundamental consequences for network coding. Theories and modeling studies based on standard Integrate...
Skander Mensi, Olivier Hagens, Wulfram Gerstner, C...
PLOSCB
2016
70views more  PLOSCB 2016»
3 years 15 days ago
Training Excitatory-Inhibitory Recurrent Neural Networks for Cognitive Tasks: A Simple and Flexible Framework
The ability to simultaneously record from large numbers of neurons in behaving animals has ushered in a new era for the study of the neural circuit mechanisms underlying cognitive...
H. Francis Song, Guangyu R. Yang, Xiao-Jing Wang
PLOSCB
2016
61views more  PLOSCB 2016»
3 years 15 days ago
Quantifying Transmission Investment in Malaria Parasites
Many microparasites infect new hosts with specialized life stages, requiring a subset of the parasite population to forgo proliferation and develop into transmission forms. Transm...
Megan A. Greischar, Nicole Mideo, Andrew F. Read, ...
PLOSCB
2016
68views more  PLOSCB 2016»
3 years 15 days ago
Recovery of Dynamics and Function in Spiking Neural Networks with Closed-Loop Control
There is a growing interest in developing novel brain stimulation methods to control disease-related aberrant neural activity and to address basic neuroscience questions. Conventi...
Ioannis Vlachos, Taskin Deniz, Ad Aertsen, Arvind ...
PLOSCB
2016
88views more  PLOSCB 2016»
3 years 15 days ago
Neurally Encoding Time for Olfactory Navigation
In Jun Park, Andrew M. Hein, Yuriy V. Bobkov, Matt...
PLOSCB
2016
69views more  PLOSCB 2016»
3 years 15 days ago
Somato-dendritic Synaptic Plasticity and Error-backpropagation in Active Dendrites
In the last decade dendrites of cortical neurons have been shown to nonlinearly combine synaptic inputs by evoking local dendritic spikes. It has been suggested that these nonline...
Mathieu Schiess, Robert Urbanczik, Walter Senn
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