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BMCBI
2007
119views more  BMCBI 2007»
14 years 12 months ago
A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments
Background: Gas chromatography-mass spectrometry (GC-MS) is a robust platform for the profiling of certain classes of small molecules in biological samples. When multiple samples ...
Mark D. Robinson, David P. De Souza, Woon Wai Keen...
BMCBI
2007
122views more  BMCBI 2007»
14 years 12 months ago
TAP score: torsion angle propensity normalization applied to local protein structure evaluation
Background: Experimentally determined protein structures may contain errors and require validation. Conformational criteria based on the Ramachandran plot are mainly used to disti...
Silvio C. E. Tosatto, Roberto Battistutta
BMCBI
2006
102views more  BMCBI 2006»
14 years 12 months ago
Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of
Background: The Thymidine kinase (Tk) mutants generated from the widely used L5178Y mouse lymphoma assay fall into two categories, small colony and large colony. Cells from the la...
Tao Han, Jianyong Wang, Weida Tong, Martha M. Moor...
BMCBI
2005
84views more  BMCBI 2005»
14 years 11 months ago
Information theory-based algorithm for in silico prediction of PCR products with whole genomic sequences as templates
Background: A new algorithm for assessing similarity between primer and template has been developed based on the hypothesis that annealing of primer to template is an information ...
Youfang Cao, Lianjie Wang, Kexue Xu, Chunhai Kou, ...
BMCBI
2004
134views more  BMCBI 2004»
14 years 11 months ago
Bayesian model accounting for within-class biological variability in Serial Analysis of Gene Expression (SAGE)
Background: An important challenge for transcript counting methods such as Serial Analysis of Gene Expression (SAGE), "Digital Northern" or Massively Parallel Signature ...
Ricardo Z. N. Vêncio, Helena Brentani, Diogo...