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» Efficient protein alignment algorithm for protein search
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BMCBI
2005
152views more  BMCBI 2005»
14 years 11 months ago
Improved profile HMM performance by assessment of critical algorithmic features in SAM and HMMER
Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
Markus Wistrand, Erik L. L. Sonnhammer
NAR
1998
122views more  NAR 1998»
14 years 11 months ago
The PIR-International Protein Sequence Database
The Protein Information Resource (PIR; http://wwwnbrf.georgetown.edu/pir/ ) supports research on molecular evolution, functional genomics, and computational biology by maintaining...
Winona C. Barker, John S. Garavelli, Daniel H. Haf...
BMCBI
2002
133views more  BMCBI 2002»
14 years 11 months ago
Identification and characterization of subfamily-specific signatures in a large protein superfamily by a hidden Markov model app
Background: Most profile and motif databases strive to classify protein sequences into a broad spectrum of protein families. The next step of such database studies should include ...
Kevin Truong, Mitsuhiko Ikura
BMCBI
2010
156views more  BMCBI 2010»
14 years 11 months ago
Protein complex prediction via verifying and reconstructing the topology of domain-domain interactions
Background: High-throughput methods for detecting protein-protein interactions enable us to obtain large interaction networks, and also allow us to computationally identify the as...
Yosuke Ozawa, Rintaro Saito, Shigeo Fujimori, Hisa...
JBI
2008
137views Bioinformatics» more  JBI 2008»
14 years 11 months ago
Mining sequential patterns for protein fold recognition
Protein data contain discriminative patterns that can be used in many beneficial applications if they are defined correctly. In this work sequential pattern mining (SPM) is utiliz...
Themis P. Exarchos, Costas Papaloukas, Christos La...