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BIOINFORMATICS
2006
15 years 6 months ago
2006
The key requirement for successful immunochemical assay is the availability of antibodies with high specificity and desired affinity. Small molecules, when used as haptens, are no...
151
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BMCBI
2006
2006
Searching for interpretable rules for disease mutations: a simulated annealing bump hunting strategy
15 years 6 months ago
Background: Understanding how amino acid substitutions affect protein functions is critical for the study of proteins and their implications in diseases. Although methods have bee...
169
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BMCBI
2006
15 years 6 months ago
2006
Background: Multiple sequence alignment is the foundation of many important applications in bioinformatics that aim at detecting functionally important regions, predicting protein...
210
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BMCBI
2006
15 years 6 months ago
2006
Background: Genome annotation can be viewed as an incremental, cooperative, data-driven, knowledge-based process that involves multiple methods to predict gene locations and struc...
160
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BMCBI
2007
15 years 6 months ago
2007
Background: Structure elucidation of unknown small molecules by mass spectrometry is a challenge despite advances in instrumentation. The first crucial step is to obtain correct e...