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BMCBI
2010
153views more  BMCBI 2010»
14 years 10 months ago
GOAL: A software tool for assessing biological significance of genes groups
Background: Modern high throughput experimental techniques such as DNA microarrays often result in large lists of genes. Computational biology tools such as clustering are then us...
Alain B. Tchagang, Alexander Gawronski, Hugo B&eac...
BMCBI
2010
154views more  BMCBI 2010»
14 years 10 months ago
Binary image representation of a ligand binding site: its application to efficient sampling of a conformational ensemble
Background: Modelling the ligand binding site of a protein is an important component of understanding proteinligand interactions and is being actively studied. Even if the side ch...
Edon Sung, Sangsoo Kim, Whanchul Shin
BMCBI
2010
116views more  BMCBI 2010»
14 years 10 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
BMCBI
2010
165views more  BMCBI 2010»
14 years 10 months ago
Multivariate meta-analysis of proteomics data from human prostate and colon tumours
Background: There is a vast need to find clinically applicable protein biomarkers as support in cancer diagnosis and tumour classification. In proteomics research, a number of met...
Lina Hultin Rosenberg, Bo Franzén, Gert Aue...
BMCBI
2010
119views more  BMCBI 2010»
14 years 10 months ago
Coherent pipeline for biomarker discovery using mass spectrometry and bioinformatics
Background: Robust biomarkers are needed to improve microbial identification and diagnostics. Proteomics methods based on mass spectrometry can be used for the discovery of novel ...
Ali Al-Shahib, Raju Misra, Nadia Ahmod, Min Fang, ...