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BMCBI
2010
103views more  BMCBI 2010»
15 years 5 months ago
A method of predicting changes in human gene splicing induced by genetic variants in context of cis-acting elements
Background: Polymorphic variants and mutations disrupting canonical splicing isoforms are among the leading causes of human hereditary disorders. While there is a substantial evid...
Alexander G. Churbanov, Igor Vorechovsky, Chindo H...
IPPS
2006
IEEE
15 years 11 months ago
A method to improve structural modeling based on conserved domain clusters
—Homology modeling requires an accurate alignment between a query sequence and its homologs with known three-dimensional (3D) information. Current structural modeling techniques ...
Fa Zhang, Lin Xu, Bo Yuan
ISPD
2005
ACM
151views Hardware» more  ISPD 2005»
15 years 11 months ago
Multilevel generalized force-directed method for circuit placement
Automatic circuit placement has received renewed interest recently given the rapid increase of circuit complexity, increase of interconnect delay, and potential sub-optimality of ...
Tony F. Chan, Jason Cong, Kenton Sze
BMCBI
2008
136views more  BMCBI 2008»
15 years 5 months ago
An efficient method for the prediction of deleterious multiple-point mutations in the secondary structure of RNAs using suboptim
Background: RNAmute is an interactive Java application which, given an RNA sequence, calculates the secondary structure of all single point mutations and organizes them into categ...
Alexander Churkin, Danny Barash
BMCBI
2006
60views more  BMCBI 2006»
15 years 5 months ago
Use of a multi-way method to analyze the amino acid composition of a conserved group of orthologous proteins in prokaryotes
Background: Amino acids in proteins are not used equally. Some of the differences in the amino acid composition of proteins are between species (mainly due to nucleotide compositi...
Alberto Pasamontes, Santiago Garcia-Vallvé