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» Predicting protein function from domain content
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BMCBI
2007
143views more  BMCBI 2007»
15 years 5 months ago
An adaptive bin framework search method for a beta-sheet protein homopolymer model
Background: The problem of protein structure prediction consists of predicting the functional or native structure of a protein given its linear sequence of amino acids. This probl...
Alena Shmygelska, Holger H. Hoos
BMCBI
2008
114views more  BMCBI 2008»
15 years 5 months ago
Combining classifiers for improved classification of proteins from sequence or structure
Background: Predicting a protein's structural or functional class from its amino acid sequence or structure is a fundamental problem in computational biology. Recently, there...
Iain Melvin, Jason Weston, Christina S. Leslie, Wi...
BMCBI
2006
130views more  BMCBI 2006»
15 years 5 months ago
Identifying biological concepts from a protein-related corpus with a probabilistic topic model
Background: Biomedical literature, e.g., MEDLINE, contains a wealth of knowledge regarding functions of proteins. Major recurring biological concepts within such text corpora repr...
Bin Zheng, David C. McLean Jr, Xinghua Lu
BMCBI
2006
102views more  BMCBI 2006»
15 years 5 months ago
Taking U out, with two nucleases?
Background: REX1 and REX2 are protein components of the RNA editing complex (the editosome) and function as exouridylylases. The exact roles of REX1 and REX2 in the editosome are ...
I. Saira Mian, Elizabeth A. Worthey, Reza Salavati
BMCBI
2007
145views more  BMCBI 2007»
15 years 5 months ago
Genome bioinformatic analysis of nonsynonymous SNPs
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the mos...
David F. Burke, Catherine L. Worth, Eva-Maria Prie...