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» The Equivalence between Biology and Computation
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BMCBI
2007
128views more  BMCBI 2007»
14 years 11 months ago
A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand bindin
Background: An accurate description of protein shape derived from protein structure is necessary to establish an understanding of protein-ligand interactions, which in turn will l...
Lei Xie, Philip E. Bourne
ALIFE
2005
14 years 11 months ago
Material Representations: From the Genetic Code to the Evolution of Cellular Automata
We present a new definition of the concept of representation for cognitive science that is based on a study of the origin of structures that are used to store memory in evolving sy...
Luis Mateus Rocha, Wim Hordijk
BMCBI
2005
104views more  BMCBI 2005»
14 years 11 months ago
Scoring functions for transcription factor binding site prediction
Background: Transcription factor binding site (TFBS) prediction is a difficult problem, which requires a good scoring function to discriminate between real binding sites and backg...
Markus T. Friberg, Peter von Rohr, Gaston H. Gonne...
BMCBI
2004
135views more  BMCBI 2004»
14 years 11 months ago
Determination of the differentially expressed genes in microarray experiments using local FDR
Background: Thousands of genes in a genomewide data set are tested against some null hypothesis, for detecting differentially expressed genes in microarray experiments. The expect...
Julie Aubert, Avner Bar-Hen, Jean-Jacques Daudin, ...
BMCBI
2004
136views more  BMCBI 2004»
14 years 11 months ago
A SNP-centric database for the investigation of the human genome
Background: Single Nucleotide Polymorphisms (SNPs) are an increasingly important tool for genetic and biomedical research. Although current genomic databases contain information o...
Alberto Riva, Isaac S. Kohane