Identification of functional modules in a PPI network by clique percolation clustering

Large-scale experiments and data integration have provided the opportunity to systematically analyze and comprehensively understand the topology of biological networks and biochemical processes in cells. Modular architecture which encompasses groups of genes/proteins involved in elementary biological functional units is a basic form of the organization of interacting proteins. Here we apply a graph clustering algorithm based on clique percolation clustering to detect overlapping network modules of a protein

• Type: Journal
• Year: 2006
• Where: CANDC
• Authors: Shi-Hua Zhang, Xue-Mei Ning, Xiang-Sun Zhang
• Keywords: Biological Functional Units, Biological Networks, CANDC 2006, Data Integration, Emerging Technology