Sciweavers

Share
MICCAI
2010
Springer

Appearance Normalization of Histology Slides

10 years 10 months ago
Appearance Normalization of Histology Slides
Abstract. This paper presents a method for automatic color and intensity normalization of digitized histology slides stained with two different agents. In comparison to previous approaches, prior information on the stain vectors is used in the estimation process, resulting in improved stability of the estimates. Due to the prevalence of hematoxylin and eosin staining for histology slides, the proposed method has significant practical utility. In particular, it can be used as a first step to standardize appearances across slides, that is very effective at countering effects due to differing stain amounts and protocols, and to slide fading. The approach is validated using synthetic experiments and 13 real datasets.
Marc Niethammer, David Borland, J. S. Marron, John
Added 29 Jan 2011
Updated 29 Jan 2011
Type Journal
Year 2010
Where MICCAI
Authors Marc Niethammer, David Borland, J. S. Marron, John T. Woosley, Nancy E. Thomas
Comments (0)
books