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ISBI
2011
IEEE

Atlas-based fiber clustering for multi-subject analysis of high angular resolution diffusion imaging tractography

8 years 6 months ago
Atlas-based fiber clustering for multi-subject analysis of high angular resolution diffusion imaging tractography
High angular resolution diffusion imaging (HARDI) allows in vivo analysis of the white matter structure and connectivity. Based on orientation distribution functions (ODFs) that represent the directionality of water diffusion at each point in the brain, tractography methods can recover major axonal pathways. This enables tract-based analysis of fiber integrity and connectivity. For multi-subject comparisons, fibers may be clustered into bundles that are consistently found across subjects. To do this, we scanned 20 young adults with HARDI at 4 T. From the reconstructed ODFs, we performed wholebrain tractography with a novel Hough transform method. We then used measures of agreement between the extracted 3D curves and a co-registered probabilistic DTI atlas to select key pathways. Using median filtering and a shortest path graph search, we derived the maximum density path to compactly represent each tract in the population. With this tract-based method, we performed tract-based analy...
Gautam Prasad, Neda Jahanshad, Iman Aganj, Christo
Added 21 Aug 2011
Updated 21 Aug 2011
Type Journal
Year 2011
Where ISBI
Authors Gautam Prasad, Neda Jahanshad, Iman Aganj, Christophe Lenglet, Guillermo Sapiro, Arthur W. Toga, Paul M. Thompson
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