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BMCBI
2007

AUG_hairpin: prediction of a downstream secondary structure influencing the recognition of a translation start site

10 years 4 months ago
AUG_hairpin: prediction of a downstream secondary structure influencing the recognition of a translation start site
Background: The translation start site plays an important role in the control of translation efficiency of eukaryotic mRNAs. The recognition of the start AUG codon by eukaryotic ribosomes is considered to depend on its nucleotide context. However, the fraction of eukaryotic mRNAs with the start codon in a suboptimal context is relatively large. It may be expected that mRNA should possess some features providing efficient translation, including the proper recognition of a translation start site. It has been experimentally shown that a downstream hairpin located in certain positions with respect to start codon can compensate in part for the suboptimal AUG context and also increases translation from non-AUG initiation codons. Prediction of such a compensatory hairpin may be useful in the evaluation of eukaryotic mRNA translation properties. Results: We evaluated interdependency between the start codon context and mRNA secondary structure at the CDS beginning: it was found that a suboptim...
Alexey V. Kochetov, Andrey Palyanov, Igor I. Titov
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2007
Where BMCBI
Authors Alexey V. Kochetov, Andrey Palyanov, Igor I. Titov, Dmitry A. Grigorovich, Akinori Sarai, Nikolay A. Kolchanov
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