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SCFBM
2008

Boolean network simulations for life scientists

9 years 10 months ago
Boolean network simulations for life scientists
Modern life sciences research increasingly relies on computational solutions, from large scale data analyses to theoretical modeling. Within the theoretical models Boolean networks occupy an increasing role as they are eminently suited at mapping biological observations and hypotheses into a mathematical formalism. The conceptual underpinnings of Boolean modeling are very accessible even without a background in quantitative sciences, yet it allows life scientists to describe and explore a wide range of surprisingly complex phenomena. In this paper we provide a clear overview of the concepts used in Boolean simulations, present a software library that can perform these simulations based on simple text inputs and give three case studies. The large scale simulations in these case studies demonstrate the Boolean paradigms and their applicability as well as the advanced features and complex use cases that our software package allows. Our software is distributed via a liberal Open Source li...
István Albert, Juilee Thakar, Song Li, Ranr
Added 28 Dec 2010
Updated 28 Dec 2010
Type Journal
Year 2008
Where SCFBM
Authors István Albert, Juilee Thakar, Song Li, Ranran Zhang, Réka Albert
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