Classification of viral zoonosis through receptor pattern analysis

9 years 11 months ago
Classification of viral zoonosis through receptor pattern analysis
Background: Viral zoonosis, the transmission of a virus from its primary vertebrate reservoir species to humans, requires ubiquitous cellular proteins known as receptor proteins. Zoonosis can occur not only through direct transmission from vertebrates to humans, but also through intermediate reservoirs or other environmental factors. Viruses can be categorized according to genotype (ssDNA, dsDNA, ssRNA and dsRNA viruses). Among them, the RNA viruses exhibit particularly high mutation rates and are especially problematic for this reason. Most zoonotic viruses are RNA viruses that change their envelope proteins to facilitate binding to various receptors of host species. In this study, we sought to predict zoonotic propensity through the analysis of receptor characteristics. We hypothesized that the major barrier to interspecies virus transmission is that receptor sequences vary among species–in other words, that the specific amino acid sequence of the receptor determines the ability o...
Se-Eun Bae, Hyeon Seok Son
Added 12 May 2011
Updated 12 May 2011
Type Journal
Year 2011
Authors Se-Eun Bae, Hyeon Seok Son
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