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BMCBI
2002

Expression profiling of human renal carcinomas with functional taxonomic analysis

8 years 4 months ago
Expression profiling of human renal carcinomas with functional taxonomic analysis
Background: Molecular characterization has contributed to the understanding of the inception, progression, treatment and prognosis of cancer. Nucleic acid array-based technologies extend molecular characterization of tumors to thousands of gene products. To effectively discriminate between tumor sub-types, reliable laboratory techniques and analytic methods are required. Results: We derived mRNA expression profiles from 21 human tissue samples (eight normal kidneys and 13 kidney tumors) and two pooled samples using the Affymetrix GeneChip platform. A panel of ten clustering algorithms combined with four data pre-processing methods identified a consensus cluster dendrogram in 18 of 40 analyses and of these 16 used a logarithmic transformation. Within the consensus dendrogram the expression profiles of the samples grouped according to tissue type; clear cell and chromophobe carcinomas displayed distinctly different gene expression patterns. By using a rigorous statistical selection base...
Michael A. Gieseg, Theresa Cody, Michael Z. Man, S
Added 17 Dec 2010
Updated 17 Dec 2010
Type Journal
Year 2002
Where BMCBI
Authors Michael A. Gieseg, Theresa Cody, Michael Z. Man, Steven J. Madore, Mark A. Rubin, Eric P. Kaldjian
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