Family specific rates of protein evolution

: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework. We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.

• Type: Journal
• Year: 2006
• Where: BIOINFORMATICS
• Authors: Hannes Luz, Martin Vingron
• Keywords: BIOINFORMATICS 2006, Eukaryotic Protein Families, Evolutionary Rate, Protein