A Gene Network Model for Developing Cell Lineages

Biological development is a remarkably complex process. A single cell, in an appropriate environment, contains sufficient information to generate a variety of differentiated cell types, whose spatial and temporal dynamics interact to form detailed morphological patterns. While several different physical and chemical processes play an important role in the development of an organism, the locus of control is the cell's gene regulatory network. We designed dynamic recurrent gene network (DRGN) model and evaluated its ability to control the developmental trajectories of cells during embryogenesis. Three tasks were developed to evaluate the model, inspired by cell lineage specification in C. elegans, describing the variation Corresponding author. 1 

• Type: Journal
• Year: 2005
• Where: ALIFE
• Authors: Nicholas Geard, Janet Wiles
• Keywords: ALIFE 2005, ALIFE 2007, Cell, Detailed Morphological Patterns, Gene Regulatory Network