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2005
ACM

Graphical rule-based representation of signal-transduction networks

7 years 5 months ago
Graphical rule-based representation of signal-transduction networks
The process by which a cell senses and responds to its environment, as in signal transduction, is often mediated by a network of protein-protein interactions, in which proteins combine to form complexes and undergo post-translational modifications, which regulate their enzymatic and binding activities. A typical signaling protein contains multiple sites of protein interaction and modification and may contain catalytic domains. As a result, interactions of signaling proteins have the potential to generate a combinatorially large number of complexes and modified states, and representing signal-transduction networks can be challenging. Representation, in the form of a diagram or model, usually involves a tradeoff between comprehensibility and precision: comprehensible representations tend to be ambiguous or incomplete, whereas precise representations, such as a long list of chemical species and reactions in a network, tend to be incomprehensible. Here, we develop conventions for repr...
James R. Faeder, Michael L. Blinov, William S. Hla
Added 26 Jun 2010
Updated 26 Jun 2010
Type Conference
Year 2005
Where SAC
Authors James R. Faeder, Michael L. Blinov, William S. Hlavacek
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