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KDD
2008
ACM

Identifying biologically relevant genes via multiple heterogeneous data sources

9 years 10 months ago
Identifying biologically relevant genes via multiple heterogeneous data sources
Selection of genes that are differentially expressed and critical to a particular biological process has been a major challenge in post-array analysis. Recent development in bioinformatics has made various data sources available such as mRNA and miRNA expression profiles, biological pathway and gene annotation, etc. Efficient and effective integration of multiple data sources helps enrich our knowledge about the involved samples and genes for selecting genes bearing significant biological relevance. In this work, we studied a novel problem of multi-source gene selection: given multiple heterogeneous data sources (or data sets), select genes from expression profiles by integrating information from various data sources. We investigated how to effectively employ information contained in multiple data sources to extract an intrinsic global geometric pattern and use it in covariance analysis for gene selection. We designed and conducted experiments to systematically compare the proposed ap...
Zheng Zhao, Jiangxin Wang, Huan Liu, Jieping Ye, Y
Added 30 Nov 2009
Updated 30 Nov 2009
Type Conference
Year 2008
Where KDD
Authors Zheng Zhao, Jiangxin Wang, Huan Liu, Jieping Ye, Yung Chang
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