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BMCBI
2007

A Latent Variable Approach for Meta-Analysis of Gene Expression Data from Multiple Microarray Experiments

9 years 11 months ago
A Latent Variable Approach for Meta-Analysis of Gene Expression Data from Multiple Microarray Experiments
Background: With the explosion in data generated using microarray technology by different investigators working on similar experiments, it is of interest to combine results across multiple studies. Results: In this article, we describe a general probabilistic framework for combining highthroughput genomic data from several related microarray experiments using mixture models. A key feature of the model is the use of latent variables that represent quantities that can be combined across diverse platforms. We consider two methods for estimation of an index termed the probability of expression (POE). The first, reported in previous work by the authors, involves Markov Chain Monte Carlo (MCMC) techniques. The second method is a faster algorithm based on the expectation-maximization (EM) algorithm. The methods are illustrated with application to a meta-analysis of datasets for metastatic cancer. Conclusion: The statistical methods described in the paper are available as an R package,
Hyungwon Choi, Ronglai Shen, Arul M. Chinnaiyan, D
Added 08 Dec 2010
Updated 08 Dec 2010
Type Journal
Year 2007
Where BMCBI
Authors Hyungwon Choi, Ronglai Shen, Arul M. Chinnaiyan, Debashis Ghosh
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