Mining frequent patterns for AMP-activated protein kinase regulation on skeletal muscle

Background: AMP-activated protein kinase (AMPK) has emerged as a significant signaling intermediary that regulates metabolisms in response to energy demand and supply. An investigation into the degree of activation and deactivation of AMPK subunits under exercise can provide valuable data for understanding AMPK. In particular, the effect of AMPK on muscle cellular energy status makes this protein a promising pharmacological target for disease treatment. As more AMPK regulation data are accumulated, data mining techniques can play an important role in identifying frequent patterns in the data. Association rule mining, which is commonly used in market basket analysis, can be applied to AMPK regulation. Results: This paper proposes a framework that can identify the potential correlation, either between the state of isoforms of , and subunits of AMPK, or between stimulus factors and the state of isoforms. Our approach is to apply item constraints in the closed interpretation to the item...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Qingfeng Chen, Yi-Ping Phoebe Chen
• Keywords: AMPK, BMCBI 2006, Isoforms, Subunit