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BMCBI
2008

mtDNAmanager: a Web-based tool for the management and quality analysis of mitochondrial DNA control-region sequences

9 years 5 months ago
mtDNAmanager: a Web-based tool for the management and quality analysis of mitochondrial DNA control-region sequences
Background: For the past few years, scientific controversy has surrounded the large number of errors in forensic and literature mitochondrial DNA (mtDNA) data. However, recent research has shown that using mtDNA phylogeny and referring to known mtDNA haplotypes can be useful for checking the quality of sequence data. Results: We developed a Web-based bioinformatics resource "mtDNAmanager" that offers a convenient interface supporting the management and quality analysis of mtDNA sequence data. The mtDNAmanager performs computations on mtDNA control-region sequences to estimate the most-probable mtDNA haplogroups and retrieves similar sequences from a selected database. By the phased designation of the most-probable haplogroups (both expected and estimated haplogroups), mtDNAmanager enables users to systematically detect errors whilst allowing for confirmation of the presence of clear key diagnostic mutations and accompanying mutations. The query tools of mtDNAmanager also fac...
Hwan Young Lee, Injee Song, Eunho Ha, Sung-Bae Cho
Added 09 Dec 2010
Updated 09 Dec 2010
Type Journal
Year 2008
Where BMCBI
Authors Hwan Young Lee, Injee Song, Eunho Ha, Sung-Bae Cho, Woo Ick Yang, Kyoung-Jin Shin
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