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2011

Mutational analysis in RNAs: comparing programs for RNA deleterious mutation prediction

8 years 5 months ago
Mutational analysis in RNAs: comparing programs for RNA deleterious mutation prediction
Programs for RNA mutational analysis that are structure-based and rely on secondary structure prediction have been developed and expanded in the past several years. They can be used for a variety of purposes, such as in suggesting point mutations that will alter RNA virus replication or translation initiation, investigating the effect of deleterious and compensatory mutations in allosteric ribozymes and riboswitches, computing an optimal path of mutations to get from one ribozyme fold to another, or analyzing regulatory RNA sequences by their mutational profile. This review describes three different freeware programs (RNAMute, RDMAS and RNAmutants) that have been developed for such purposes. RNAMute and RDMAS in principle perform energy minimization prediction by available software such as RNAfold from the Vienna RNA package or Zuker’s Mfold, while RNAmutants provides an efficient method using essential ingredients from energy minimization prediction. Both RNAMute in its extended ve...
Danny Barash, Alexander Churkin
Added 12 May 2011
Updated 12 May 2011
Type Journal
Year 2011
Where BIB
Authors Danny Barash, Alexander Churkin
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