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DASFAA
2005
IEEE

PADS: Protein Structure Alignment Using Directional Shape Signatures

8 years 10 months ago
PADS: Protein Structure Alignment Using Directional Shape Signatures
A novel approach for similarity search on the protein structure databases is proposed. PADS (Protein Alignment by Directional shape Signatures) incorporates the three dimensional coordinates of the main atoms of each amino acid and extracts a geometrical shape signature along with the direction of the given amino acid. As a result, each protein is presented by a series of feature vectors representing local geometry, shape, direction, and secondary structure assignment of its amino acid constituents. Furthermore, a residue-toresidue distance matrix is calculated and is incorporated into a local alignment dynamic programming algorithm to find the similar portions of two given proteins and finally a sequence alignment step is used as the last filtration step. The optimal superimposition of the detected similar regions is used to assess the quality of the results. The proposed algorithm is fast and accurate and hence could be used for the analysis of large protein structure similarity....
S. Alireza Aghili, Divyakant Agrawal, Amr El Abbad
Added 24 Jun 2010
Updated 24 Jun 2010
Type Conference
Year 2005
Where DASFAA
Authors S. Alireza Aghili, Divyakant Agrawal, Amr El Abbadi
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