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IJCBDD
2010

Predicting protein complexes by data integration of different types of interactions

13 years 2 months ago
Predicting protein complexes by data integration of different types of interactions
: The explosion of highthroughput interaction data from proteomics studies gives us the opportunity to integrate Protein-Protein Interactions (PPI) from different type of interactions. These methods rely on the assumption that proteins within a complex have more interactions across the different data sets which translate into the identification of dense subgraphs. However, the relative importance of the types of interaction are not equivalent in their reliability and accuracy consequently they should be analysed separately. Here we propose a method that use graph theory and mathematical modelling to solve this problem. Our approach has four steps that i score independently each type of interaction ii build an interaction specific networks for each type iii Weight the specific networks and iv combine and normalise the scores. Using this approach to the BRCA1Associated genome Surveillance Complex (BASC), we correctly identified the known core components of the complex and subcomplexes th...
Powell Patrick Cheng Tan, Daryanaz Dargahi, Freder
Added 27 Jan 2011
Updated 27 Jan 2011
Type Journal
Year 2010
Where IJCBDD
Authors Powell Patrick Cheng Tan, Daryanaz Dargahi, Frederic Pio
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