Sciweavers

Share
RECOMB
2006
Springer

Integrated Protein Interaction Networks for 11 Microbes

10 years 11 months ago
Integrated Protein Interaction Networks for 11 Microbes
We have combined four different types of functional genomic data to create high coverage protein interaction networks for 11 microbes. Our integration algorithm naturally handles statistically dependent predictors and automatically corrects for differing noise levels and data corruption in different evidence sources. We find that many of the predictions in each integrated network hinge on moderate but consistent evidence from multiple sources rather than strong evidence from a single source, yielding novel biology which would be missed if a single data source such as coexpression or coinheritance was used in isolation. In addition to statistical analysis, we demonstrate via case study that these subtle interactions can discover new aspects of even well studied functional modules. Our work represents the largest collection of probabilistic protein interaction networks compiled to date, and our methods can be applied to any sequenced organism and any kind of experimental or computational...
Balaji S. Srinivasan, Antal F. Novak, Jason Flanni
Added 03 Dec 2009
Updated 03 Dec 2009
Type Conference
Year 2006
Where RECOMB
Authors Balaji S. Srinivasan, Antal F. Novak, Jason Flannick, Serafim Batzoglou, Harley H. McAdams
Comments (0)
books