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CDC
2008
IEEE

Robust closed-loop control of plasma glycemia: A discrete-delay model approach

12 years 4 months ago
Robust closed-loop control of plasma glycemia: A discrete-delay model approach
The paper investigates the problem of tracking a desired plasma glucose evolution by means of intra-venous insulin administration. A modelbased approach is followed. A recent model of the glucose/insulin regulatory system which consists of discrete-delay nonlinear diĀ®erential equations is used. A disturbance is added to the insulin kinetics in order to model uncertainties concerning both the insulin delivery rate and the mechanism actuating the insulin pump. A feedback control law which yields input-to-state stability of the closed loop error system with respect to the disturbance is provided. Such control law depends on the glucose and insulin measurements at the present and at a delayed time. In silico simulations validate the theoretical results.
Pasquale Palumbo, Pierdomenico Pepe, Simona Panunz
Added 29 May 2010
Updated 29 May 2010
Type Conference
Year 2008
Where CDC
Authors Pasquale Palumbo, Pierdomenico Pepe, Simona Panunzi, Andrea De Gaetano
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