Robust closed-loop control of plasma glycemia: A discrete-delay model approach

The paper investigates the problem of tracking a desired plasma glucose evolution by means of intra-venous insulin administration. A modelbased approach is followed. A recent model of the glucose/insulin regulatory system which consists of discrete-delay nonlinear di®erential equations is used. A disturbance is added to the insulin kinetics in order to model uncertainties concerning both the insulin delivery rate and the mechanism actuating the insulin pump. A feedback control law which yields input-to-state stability of the closed loop error system with respect to the disturbance is provided. Such control law depends on the glucose and insulin measurements at the present and at a delayed time. In silico simulations validate the theoretical results.

• Type: Conference
• Year: 2008
• Where: CDC
• Authors: Pasquale Palumbo, Pierdomenico Pepe, Simona Panunzi, Andrea De Gaetano
• Keywords: CDC 2008, Control Systems, Insulin, Insulin Delivery Rate, Intra-venous Insulin Administration