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BMCBI
2004

Structural characterization of genomes by large scale sequence-structure threading: application of reliability analysis in struc

10 years 1 months ago
Structural characterization of genomes by large scale sequence-structure threading: application of reliability analysis in struc
Background: We establish that the occurrence of protein folds among genomes can be accurately described with a Weibull function. Systems which exhibit Weibull character can be interpreted with reliability theory commonly used in engineering analysis. For instance, Weibull distributions are widely used in reliability, maintainability and safety work to model time-to-failure of mechanical devices, mechanisms, building constructions and equipment. Results: We have found that the Weibull function describes protein fold distribution within and among genomes more accurately than conventional power functions which have been used in a number of structural genomic studies reported to date. It has also been found that the Weibull reliability parameter for protein fold distributions varies between genomes and may reflect differences in rates of gene duplication in evolutionary history of organisms. Conclusions: The results of this work demonstrate that reliability analysis can provide useful in...
Artem Cherkasov, Shannan J. Ho Sui, Robert C. Brun
Added 16 Dec 2010
Updated 16 Dec 2010
Type Journal
Year 2004
Where BMCBI
Authors Artem Cherkasov, Shannan J. Ho Sui, Robert C. Brunham, Steven J. M. Jones
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