Structural comparison of metabolic networks in selected single cell organisms

Background: There has been tremendous interest in the study of biological network structure. An array of measurements has been conceived to assess the topological properties of these networks. In this study, we compared the metabolic network structures of eleven single cell organisms representing the three domains of life using these measurements, hoping to find out whether the intrinsic network design principle(s), reflected by these measurements, are different among species in the three domains of life. Results: Three groups of topological properties were used in this study: network indices, degree distribution measures and motif profile measure. All of which are higher-level topological properties except for the marginal degree distribution. Metabolic networks in Archaeal species are found to be different from those in S. cerevisiae and the six Bacterial species in almost all measured higher-level topological properties. Our findings also indicate that the metabolic network in Arch...

• Type: Journal
• Year: 2005
• Where: BMCBI
• Authors: Dongxiao Zhu, Zhaohui S. Qin
• Keywords: BMCBI 2005, Metabolic Network, Network Structures, Topological Properties