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2007

SuperHapten: a comprehensive database for small immunogenic compounds

9 years 5 months ago
SuperHapten: a comprehensive database for small immunogenic compounds
The immune system protects organisms from foreign proteins, peptide epitopes and a multitude of chemical compounds. Among these, haptens are small molecules, eliciting an immune response when conjugated with carrier molecules. Known haptens are xenobiotics or natural compounds, which can induce a number of autoimmune diseases like contact dermatitis or asthma. Furthermore, haptens are utilized in the development of biosensors, immunomodulators and new vaccines. Although hapteninduced allergies account for 6–10% of all adverse drug effects, the understanding of the correlation between structural and haptenic properties is rather fragmentary. We have developed a manually curated hapten database, SuperHapten, integrating information from literature and web resources. The current version of the database compiles 2D/3D structures, physicochemical properties and references for about 7500 haptens and 25,000 synonyms. The commercial availability is documented for about 6300 haptens and 450 ...
Stefan Günther, Dorothea Hempel, Mathias Dunk
Added 27 Dec 2010
Updated 27 Dec 2010
Type Journal
Year 2007
Where NAR
Authors Stefan Günther, Dorothea Hempel, Mathias Dunkel, Kristian Rother, Robert Preissner
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