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2011

ThYme: a database for thioester-active enzymes

7 years 9 months ago
ThYme: a database for thioester-active enzymes
The ThYme (Thioester-active enzYme; http://www .enzyme.cbirc.iastate.edu) database has been constructed to bring together amino acid sequences and 3D (tertiary) structures of all the enzymes constituting the fatty acid synthesis and polyketide synthesis cycles. These enzymes are active on thioester-containing substrates, specifically those that are parts of the acyl-CoA synthase, acyl-CoA carboxylase, acyl transferase, ketoacyl synthase, ketoacyl reductase, hydroxyacyl dehydratase, enoyl reductase and thioesterase enzyme groups. These groups have been classified into families, members of which are similar in sequences, tertiary structures and catalytic mechanisms, implying common protein ancestry. ThYme is continually updated as sequences and tertiary structures become available.
David C. Cantu, Yingfei Chen, Matthew L. Lemons, P
Added 16 Sep 2011
Updated 16 Sep 2011
Type Journal
Year 2011
Where NAR
Authors David C. Cantu, Yingfei Chen, Matthew L. Lemons, Peter J. Reilly
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