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CDC
2010
IEEE

Tuning a synthetic in vitro oscillator using control-theoretic tools

10 years 6 months ago
Tuning a synthetic in vitro oscillator using control-theoretic tools
Abstract-- This paper demonstrates the effectiveness of simple control-theoretic tools in generating simulation-guided experiments on a synthetic in vitro oscillator. A theoretical analysis of the behavior of such system is motivated by high cost, time consuming experiments, together with the excessive number of tuning parameters. A simplified model of the synthetic oscillator is chosen to capture only its essential features. The model is analyzed using the small gain theorem and the theory of describing functions. Such analysis reveals what are the parameters that primarily determine when the system can admit stable oscillations. Experimental verification of the theoretical and numerical findings is carried out and confirms the predicted results regarding the role of production and degradation rates.
Christopher Sturk, Elisa Franco, Richard M. Murray
Added 13 May 2011
Updated 13 May 2011
Type Journal
Year 2010
Where CDC
Authors Christopher Sturk, Elisa Franco, Richard M. Murray
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