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CSB
2004
IEEE
158views Bioinformatics» more  CSB 2004»
13 years 9 months ago
Algorithms for Association Study Design Using a Generalized Model of Haplotype Conservation
There is considerable interest in computational methods to assist in the use of genetic polymorphism data for locating disease-related genes. Haplotypes, contiguous sets of correl...
Russell Schwartz
BMCBI
2010
107views more  BMCBI 2010»
13 years 5 months ago
Conditional random pattern model for copy number aberration detection
Background: DNA copy number aberration (CNA) is very important in the pathogenesis of tumors and other diseases. For example, CNAs may result in suppression of anti-oncogenes and ...
Fuhai Li, Xiaobo Zhou, Wanting Huang, Chung-Che Ch...
BMCBI
2004
136views more  BMCBI 2004»
13 years 5 months ago
A SNP-centric database for the investigation of the human genome
Background: Single Nucleotide Polymorphisms (SNPs) are an increasingly important tool for genetic and biomedical research. Although current genomic databases contain information o...
Alberto Riva, Isaac S. Kohane
BMCBI
2007
200views more  BMCBI 2007»
13 years 5 months ago
Assessment of algorithms for high throughput detection of genomic copy number variation in oligonucleotide microarray data
Background: Genomic deletions and duplications are important in the pathogenesis of diseases, such as cancer and mental retardation, and have recently been shown to occur frequent...
Ágnes Baross, Allen D. Delaney, H. Irene Li...
BMCBI
2008
108views more  BMCBI 2008»
13 years 5 months ago
New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic backgroun
Background: Few genetic factors predisposing to the sporadic form of amyotrophic lateral sclerosis (ALS) have been identified, but the pathology itself seems to be a true multifac...
Silvana Penco, Massimo Buscema, Maria Cristina Pat...