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» A Methodology for Comparative Functional Genomics
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BMCBI
2008
112views more  BMCBI 2008»
13 years 6 months ago
Evaluation of genomic island predictors using a comparative genomics approach
Background: Genomic islands (GIs) are clusters of genes in prokaryotic genomes of probable horizontal origin. GIs are disproportionately associated with microbial adaptations of m...
Morgan G. I. Langille, William W. L. Hsiao, Fiona ...
ALMOB
2008
160views more  ALMOB 2008»
13 years 6 months ago
Syntenator: Multiple gene order alignments with a gene-specific scoring function
Background: Identification of homologous regions or conserved syntenies across genomes is one crucial step in comparative genomics. This task is usually performed by genome alignm...
Christian Rödelsperger, Christoph Dieterich
GECCO
2000
Springer
123views Optimization» more  GECCO 2000»
13 years 9 months ago
Genomic computing: explanatory modelling for functional genomics
Many newly discovered genes are of unknown function. DNA microarrays are a method for determining the expression levels of all genes in an organism for which a complete genome seq...
Richard J. Gilbert, Jem J. Rowland, Douglas B. Kel...
JCB
2008
144views more  JCB 2008»
13 years 6 months ago
Multi-Break Rearrangements and Breakpoint Re-Uses: From Circular to Linear Genomes
Multi-break rearrangements break a genome into multiple fragments and further glue them together in a new order. While 2-break rearrangements represent standard reversals, fusions...
Max A. Alekseyev
EDBT
2008
ACM
166views Database» more  EDBT 2008»
14 years 6 months ago
OrthoCluster: a new tool for mining synteny blocks and applications in comparative genomics
By comparing genomes among both closely and distally related species, comparative genomics analysis characterizes structures and functions of different genomes in both conserved a...
Xinghuo Zeng, Matthew J. Nesbitt, Jian Pei, Ke Wan...