In nature, one finds large collections of different protein sequences exhibiting roughly the same three-dimensional structure, and this observation underpins the study of structur...
Leonid Meyerguz, David Kempe, Jon M. Kleinberg, Ro...
Background: Protein sequence clustering has been widely used as a part of the analysis of protein structure and function. In most cases single linkage or graph-based clustering al...
Yonghui Chen, Kevin D. Reilly, Alan P. Sprague, Zh...
Background: A structure alignment method based on a local geometric property is presented and its performance is tested in pairwise and multiple structure alignments. In this appr...
Background: Elucidating protein-protein interactions (PPIs) is essential to constructing protein interaction networks and facilitating our understanding of the general principles ...
The prediction of the native structures of proteins, the socalled protein folding problem, is a NP hard multi-minima optimization problem for which to date no routine solutions ex...