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RECOMB
2006
Springer
14 years 5 months ago
2006
Springer
For as long as biologists have been computing alignments of sequences, the question of what values to use for scoring substitutions and gaps has persisted. While some choices for s...
BMCBI
2010
13 years 5 months ago
2010
Background: Genome sequence alignments form the basis of much research. Genome alignment depends on various mundane but critical choices, such as how to mask repeats and which sco...
BMCBI
2011
13 years 6 days ago
2011
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
BMCBI
2010
2010
On the use of resampling tests for evaluating statistical significance of binding-site co-occurrence
13 years 5 months ago
Background: In eukaryotes, most DNA-binding proteins exert their action as members of large effector complexes. The presence of these complexes are revealed in high-throughput gen...
BMCBI
2008
13 years 5 months ago
2008
Background: Liquid chromatography coupled to mass spectrometry (LC-MS) has become a prominent tool for the analysis of complex proteomics and metabolomics samples. In many applica...