Background: Detecting homology between remotely related protein families is an important problem in computational biology since the biological properties of uncharacterized protei...
Background: Many proposed statistical measures can efficiently compare protein sequence to further infer protein structure, function and evolutionary information. They share the s...
NCBI’s Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from...
Aron Marchler-Bauer, Shennan Lu, John B. Anderson,...
Background: Gene Ontology (GO) is a standard vocabulary of functional terms and allows for coherent annotation of gene products. These annotations provide a basis for new methods ...