25 search results - page 1 / 5 » A maximum likelihood framework for protein design |
BMCBI
2006
13 years 5 months ago
2006
Background: The aim of protein design is to predict amino-acid sequences compatible with a given target structure. Traditionally envisioned as a purely thermodynamic question, thi...
BIOINFORMATICS
2006
13 years 5 months ago
2006
: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of euka...
IJBRA
2006
13 years 4 months ago
2006
: Probabilistic models for biological sequences (DNA and proteins) are frequently used in bioinformatics. We describe statistical tests designed to detect the order of dependency a...
ESCIENCE
2006
IEEE
13 years 11 months ago
2006
IEEE
We have designed a maximum likelihood fitter using the actor model to distribute the computation over a heterogeneous network. The prototype implementation uses the SALSA program...
ESCIENCE
2007
IEEE
13 years 11 months ago
2007
IEEE
This paper presents GMLE 1 , a generic and distributed framework for maximum likelihood evaluation. GMLE is currently being applied to astroinformatics for determining the shape o...