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BIBE
2007
IEEE
128views Bioinformatics» more  BIBE 2007»
13 years 11 months ago
QOMA2: Optimizing the alignment of many sequences
Abstract—We consider the problem of aligning multiple protein sequences with the goal of maximizing the SP (Sum-of-Pairs) score, when the number of sequences is large. The QOMA (...
Xu Zhang, Tamer Kahveci
BMCBI
2010
229views more  BMCBI 2010»
13 years 5 months ago
Mocapy++ - A toolkit for inference and learning in dynamic Bayesian networks
Background: Mocapy++ is a toolkit for parameter learning and inference in dynamic Bayesian networks (DBNs). It supports a wide range of DBN architectures and probability distribut...
Martin Paluszewski, Thomas Hamelryck
FGCS
2007
107views more  FGCS 2007»
13 years 5 months ago
Algorithmic re-structuring and data replication for protein structure comparison on a GRID
This paper describes a major restructuring of PROuST, a method for protein structure comparison, for an efficient porting to the Grid. PROuST consists of different components: an...
Giovanni Ciriello, M. Comin, Concettina Guerra
BMCBI
2005
99views more  BMCBI 2005»
13 years 5 months ago
Effective ambiguity checking in biosequence analysis
Background: Ambiguity is a problem in biosequence analysis that arises in various analysis tasks solved via dynamic programming, and in particular, in the modeling of families of ...
Janina Reeder, Peter Steffen, Robert Giegerich
BMCBI
2010
116views more  BMCBI 2010»
13 years 5 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...