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BMCBI
2010
135views more  BMCBI 2010»
13 years 6 months ago
Detecting disease associated modules and prioritizing active genes based on high throughput data
Background: The accumulation of high-throughput data greatly promotes computational investigation of gene function in the context of complex biological systems. However, a biologi...
Yu-Qing Qiu, Shi-Hua Zhang, Xiang-Sun Zhang, Luona...
CSB
2005
IEEE
130views Bioinformatics» more  CSB 2005»
13 years 11 months ago
iSimBioSys: An "In Silico" Discrete Event Simulation Framework for Modeling Biological Systems
The genome projects have provided comprehensive information about the basic building blocks of life. The next challenge is to understand how biological functions emerge from compl...
Samik Ghosh, Preetam Ghosh, Kalyan Basu, Sajal K. ...
BIBE
2007
IEEE
110views Bioinformatics» more  BIBE 2007»
14 years 10 days ago
Discrete Methods for Association Search and Status Prediction in Genotype Case-Control Studies
Abstract—Recent improvements in high-throughput genotyping technology make possible genome-wide association studies and status prediction (classification) for common complex dis...
Dumitru Brinza, Alexander Zelikovsky
GECCO
2010
Springer
191views Optimization» more  GECCO 2010»
13 years 10 months ago
Initialization parameter sweep in ATHENA: optimizing neural networks for detecting gene-gene interactions in the presence of sma
Recent advances in genotyping technology have led to the generation of an enormous quantity of genetic data. Traditional methods of statistical analysis have proved insufficient i...
Emily Rose Holzinger, Carrie C. Buchanan, Scott M....
EVOW
2010
Springer
14 years 24 days ago
Grammatical Evolution Decision Trees for Detecting Gene-Gene Interactions
DEODHAR, SUSHAMNA DEODHAR. Using Grammatical Evolution Decision Trees for Detecting Gene-Gene Interactions in Genetic Epidemiology. (Under the direction of Dr. Alison Motsinger-Re...
Sushamna Deodhar, Alison A. Motsinger-Reif