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BMCBI
2008
77views more  BMCBI 2008»
13 years 5 months ago
A simple and robust method for connecting small-molecule drugs using gene-expression signatures
Background: Interaction of a drug or chemical with a biological system can result in a geneexpression profile or signature characteristic of the event. Using a suitably robust alg...
Shu-Dong Zhang, Timothy W. Gant
ESANN
2008
13 years 6 months ago
A method for robust variable selection with significance assessment
Our goal is proposing an unbiased framework for gene expression analysis based on variable selection combined with a significance assessment step. We start by discussing the need ...
Annalisa Barla, Sofia Mosci, Lorenzo Rosasco, Ales...
RECOMB
2008
Springer
14 years 5 months ago
Detecting Disease-Specific Dysregulated Pathways Via Analysis of Clinical Expression Profiles
We present a method for identifying connected gene subnetworks significantly enriched for genes that are dysregulated in specimens of a disease. These subnetworks provide a signat...
Igor Ulitsky, Richard M. Karp, Ron Shamir
BMCBI
2010
177views more  BMCBI 2010»
13 years 5 months ago
Modular composition predicts kinase/substrate interactions
Background: Phosphorylation events direct the flow of signals and metabolites along cellular protein networks. Current annotations of kinase-substrate binding events are far from ...
Yichuan Liu, Aydin Tozeren