Background: Interaction of a drug or chemical with a biological system can result in a geneexpression profile or signature characteristic of the event. Using a suitably robust alg...
Our goal is proposing an unbiased framework for gene expression analysis based on variable selection combined with a significance assessment step. We start by discussing the need ...
Annalisa Barla, Sofia Mosci, Lorenzo Rosasco, Ales...
We present a method for identifying connected gene subnetworks significantly enriched for genes that are dysregulated in specimens of a disease. These subnetworks provide a signat...
Background: Phosphorylation events direct the flow of signals and metabolites along cellular protein networks. Current annotations of kinase-substrate binding events are far from ...