Allostery is the most direct, rapid and efficient way of regulating protein function, ranging from the control of metabolic mechanisms to signaltransduction pathways. However, an ...
Zhimin Huang, Liang Zhu, Yan Cao, Geng Wu, Xinyi L...
The PROMISE (Prosthetic centres and metal ions in protein active sites) database aims to gather together comprehensive sequence, structural, functional and bibliographic informati...
Kirill Degtyarenko, A. C. North, D. N. Perkins, Jo...
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
The transcriptional regulatory sequences in metazoan genomes often consist of multiple cis-regulatory modules (CRMs). Each CRM contains locally enriched occurrences of binding site...
Computational and comparative analysis of protein-protein interaction (PPI) networks enable understanding of the modular organization of the cell through identification of functio...