44 search results - page 1 / 9 » Algorithms for Detecting Significantly Mutated Pathways in C... |
RECOMB
2010
Springer
13 years 6 months ago
2010
Springer
Abstract. Recent genome sequencing studies have shown that the somatic mutations that drive cancer development are distributed across a large number of genes. This mutational heter...
BMCBI
2010
13 years 4 months ago
2010
Background: Cancer is caused through a multistep process, in which a succession of genetic changes, each conferring a competitive advantage for growth and proliferation, leads to ...
BMCBI
2010
13 years 4 months ago
2010
Background: Prognosis is of critical interest in breast cancer research. Biomedical studies suggest that genomic measurements may have independent predictive power for prognosis. ...
RECOMB
2008
Springer
14 years 5 months ago
2008
Springer
We present a method for identifying connected gene subnetworks significantly enriched for genes that are dysregulated in specimens of a disease. These subnetworks provide a signat...
BMCBI
2007
13 years 4 months ago
2007
Background: In order to recapitulate tumor progression pathways using epigenetic data, we developed novel clustering and pathway reconstruction algorithms, collectively referred t...