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BMCBI
2010
143views more  BMCBI 2010»
13 years 2 months ago
A genome alignment algorithm based on compression
Background: Traditional genome alignment methods consider sequence alignment as a variation of the string edit distance problem, and perform alignment by matching characters of th...
Minh Duc Cao, Trevor I. Dix, Lloyd Allison
RECOMB
2002
Springer
14 years 5 months ago
Significance Of inter-species matches when evolutionary rate varies
We develop techniques to estimate the statistical significance of gap-free alignments between two genomic DNA sequences, using human-mouse alignments as an example. The sequences ...
Jia Li, Webb Miller
BMCBI
2004
200views more  BMCBI 2004»
13 years 4 months ago
ABC: software for interactive browsing of genomic multiple sequence alignment data
Background: Alignment and comparison of related genome sequences is a powerful method to identify regions likely to contain functional elements. Such analyses are data intensive, ...
Gregory M. Cooper, Senthil A. G. Singaravelu, Aren...
CORR
2007
Springer
100views Education» more  CORR 2007»
13 years 4 months ago
Identifying statistical dependence in genomic sequences via mutual information estimates
Questions of understanding and quantifying the representation and amount of information in organisms have become a central part of biological research, as they potentially hold th...
H. M. Aktulga, I. Kontoyiannis, L. A. Lyznik, Luka...
RECOMB
2005
Springer
14 years 5 months ago
A Partial Solution to the C-Value Paradox
In the half-century since the C-value paradox (the apparent lack of correlation between organismal genome size and morphological complexity) was described, there have been no expli...
Jeffrey M. Marcus